Compliance manuals are excellent vehicles to help importers and exporters ensure that they are doing everything they can to operate in conformity with the various laws and regulations under which they operate. The trick, however, is in deciding what actually needs to go into the manual.
A good jumping off point is to take a realistic look at the way your enterprise operates, and then ascertain what kinds of risk your various activities present to a regulator.
Binding rulings allow an importer to get a determination on the correct classification and duty rate for their products in advance of importation. A binding ruling request can be submitted electronically or in a letter to the CBP Information Exchange, National Commodity Specialist with a detailed description of the product along with relevant specifications, descriptive literature and samples. The importer generally receives a response within 30 days. Once Customs issues the ruling, the classification is binding for all US ports. 

I’ve always found it interesting that so many healthcare companies that import chemicals and pharmaceuticals have such a difficult time with import compliance. These companies typically have solid regulatory compliance knowledge regarding the FDA, Departments of Agriculture, Consumer Product Safety Commission and many other agencies and have access to chemists and manufacturing product experts. It’s never as easy as it appears.